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To accommodate their narrow bodies, snakes' paired organs (such as kidneys) appear one in front of the other instead of side by side, and most have only one functional lung.Some species retain a pelvic girdle with a pair of vestigial claws on either side of the cloaca.
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Early in snake evolution, the Hox gene expression in the axial skeleton responsible for the development of the thorax became dominant.
As a result, the vertebrae anterior to the hindlimb buds (when present) all have the same thoracic-like identity (except from the atlas, axis, and 1–3 neck vertebrae).
Like all squamates, snakes are ectothermic, amniote vertebrates covered in overlapping scales.
Many species of snakes have skulls with several more joints than their lizard ancestors, enabling them to swallow prey much larger than their heads with their highly mobile jaws.